David C Henshall Selected Research

Antisense Oligonucleotides

11/2021	Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice.
1/2021	Systemic delivery of antagomirs during blood-brain barrier disruption is disease-modifying in experimental epilepsy.
1/2020	Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice.
7/2019	Targeting microRNA-134 for seizure control and disease modification in epilepsy.
12/2016	MicroRNAs in epilepsy: pathophysiology and clinical utility.
4/2004	Bim regulation may determine hippocampal vulnerability after injurious seizures and in temporal lobe epilepsy.

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David C Henshall Research Topics

Disease

88	Seizures (Absence Seizure) 01/2024 - 07/2002
71	Epilepsy (Aura) 01/2024 - 07/2002
55	Status Epilepticus (Complex Partial Status Epilepticus) 10/2023 - 02/2008
27	Temporal Lobe Epilepsy 01/2024 - 04/2004
14	Inflammation (Inflammations) 01/2023 - 01/2011
14	Brain Injuries (Brain Injury) 10/2020 - 09/2002
8	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2024 - 01/2004
8	Gliosis 01/2023 - 06/2008
8	Neuroinflammatory Diseases 01/2023 - 01/2013
5	Brain Diseases (Brain Disorder) 01/2023 - 01/2017
5	Nervous System Diseases (Neurological Disorders) 01/2023 - 07/2012
5	Hypoxia (Hypoxemia) 01/2023 - 11/2015
5	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2004
5	Ischemia 06/2011 - 09/2002
4	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/2015 - 01/2003
3	Schizophrenia (Dementia Praecox) 01/2022 - 05/2017
3	Pathologic Processes 01/2020 - 01/2016
3	Drug Resistant Epilepsy 12/2019 - 09/2012
3	Hippocampal Sclerosis 03/2015 - 01/2012
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2022 - 05/2011
2	Neoplasms (Cancer) 01/2021 - 12/2007
2	Cognitive Dysfunction 11/2019 - 10/2019
2	Metabolic Bone Diseases (Osteopenia) 01/2018 - 10/2016
2	Hypophosphatasia 01/2018 - 10/2016
2	AIDS-Related Complex (ARC) 01/2017 - 05/2011
2	Infarction (Infarctions) 01/2015 - 11/2004
2	Brain Ischemia (Cerebral Ischemia) 02/2009 - 01/2003

Drug/Important Bio-Agent (IBA)

46	Kainic Acid (Kainate)IBA 01/2024 - 07/2002
44	MicroRNAs (MicroRNA)IBA 01/2024 - 11/2011
39	Proteins (Proteins, Gene)FDA Link 01/2024 - 05/2003
26	Biomarkers (Surrogate Marker)IBA 01/2023 - 04/2014
18	Purinergic P2X7 ReceptorsIBA 01/2023 - 01/2012
14	Adenosine Triphosphate (ATP)IBA 01/2023 - 09/2013
12	AntagomirsIBA 11/2021 - 07/2012
9	RNA (Ribonucleic Acid)IBA 01/2024 - 01/2017
9	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022 - 01/2012
7	OligonucleotidesIBA 01/2021 - 09/2013
6	Antisense OligonucleotidesIBA 11/2021 - 04/2004
5	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021 - 11/2013
5	Protein Isoforms (Isoforms)IBA 01/2018 - 10/2006
5	Transcription Factors (Transcription Factor)IBA 12/2016 - 04/2004
5	CaspasesIBA 03/2009 - 05/2002
4	Messenger RNA (mRNA)IBA 01/2024 - 01/2016
4	EnzymesIBA 01/2024 - 01/2003
4	Pentylenetetrazole (Metrazol)IBA 01/2023 - 03/2017
4	Pilocarpine (Ocusert)FDA LinkGeneric 10/2021 - 07/2015
4	CytokinesIBA 01/2021 - 01/2011
4	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2003
4	locked nucleic acidIBA 01/2018 - 09/2013
4	Type I Tumor Necrosis Factor ReceptorsIBA 01/2011 - 05/2003
4	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2011 - 09/2003
3	ElementsIBA 10/2023 - 02/2005
3	Carrier Proteins (Binding Protein)IBA 10/2023 - 01/2012
3	JNJ-47965567IBA 01/2023 - 01/2016
3	ConvulsantsIBA 01/2022 - 06/2008
3	Lorazepam (Ativan)FDA LinkGeneric 01/2022 - 04/2004
3	Ion Channels (Ion Channel)IBA 01/2021 - 01/2015
3	Phenobarbital (Luminal)FDA Link 01/2018 - 11/2015
3	3- (5- (2,3- dichlorophenyl)- 1H- tetrazol- 1- yl)methylpyridineIBA 01/2017 - 09/2013
3	Oxygen (Dioxygen)IBA 11/2015 - 02/2005
3	BenzodiazepinesIBA 10/2015 - 04/2012
3	CalciumIBA 08/2015 - 04/2004
3	14-3-3 Proteins (14-3-3 Protein)IBA 01/2012 - 06/2008
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2011 - 09/2003
3	Death Domain ReceptorsIBA 02/2008 - 04/2004
3	Death-Associated Protein KinasesIBA 04/2004 - 09/2003
3	Caspase 8 (Caspase-8)IBA 04/2004 - 09/2003
2	Circulating MicroRNAIBA 01/2023 - 10/2020
2	LipopolysaccharidesIBA 01/2022 - 11/2004
2	Midazolam (Versed)FDA LinkGeneric 01/2022 - 10/2015
2	Blood Proteins (Serum Proteins)IBA 01/2021 - 02/2013
2	Transfer RNA (tRNA)IBA 01/2020 - 01/2019
2	ChromatinIBA 10/2018 - 02/2005
2	Untranslated RNA (Noncoding RNA)IBA 01/2018 - 03/2015
2	Vitamin B 6IBA 01/2018 - 10/2016
2	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2018 - 10/2016
2	Alkaline PhosphataseIBA 01/2018 - 10/2016
2	Proteasome Endopeptidase Complex (Proteasome)IBA 07/2017 - 01/2017
2	salicylhydroxamic acid (SHAM)IBA 07/2017 - 12/2008
2	CholesterolIBA 03/2017 - 10/2012
2	Purinergic Receptors (Receptors, Purine)IBA 01/2016 - 08/2015
2	CationsIBA 01/2016 - 06/2014
2	Purinergic P2X4 ReceptorsIBA 01/2016 - 11/2013
2	Caspase 3 (Caspase-3)IBA 11/2015 - 04/2006
2	Molecular Chaperones (Chaperone, Molecular)IBA 06/2015 - 05/2003
2	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 02/2005
2	LigandsIBA 11/2013 - 01/2012
2	Immunoglobulin G (IgG)IBA 02/2013 - 09/2012
2	Bcl-2-Like Protein 11IBA 06/2011 - 04/2004
2	Dopamine (Intropin)FDA LinkGeneric 05/2011 - 06/2008
2	Neuropeptide YIBA 01/2010 - 06/2008
2	Calmodulin (Calcium-Dependent Activator Protein)IBA 04/2004 - 09/2003
2	Diazepam (Valium)FDA LinkGeneric 04/2004 - 09/2002
1	MelatoninIBA 10/2023

Therapy/Procedure

14	Therapeutics 01/2023 - 01/2004
4	Drug Therapy (Chemotherapy) 01/2022 - 10/2015
3	Injections 01/2024 - 01/2016
2	Induced Hyperthermia (Thermotherapy) 09/2022 - 01/2022
2	Intraperitoneal Injections 01/2021 - 06/2014
1	Cell- and Tissue-Based Therapy (Cell Therapy) 12/2023